Effect of Spirulina (Spirulina platensis) And Riboflavin Against Arsenic Toxicity In Rat
Author:
Shefaly Akter, Md. Mahmudul Hasan, Rakibul Islam, Fahima Binthe Aziz, Mst. Misrat Masuma Parvez, Sharmin Akter Ripa, Tahmina Akter, & Md. Hannan Ali
Abstract
This study was undertaken to observe the effects of spirulina (Spirulina platensis) and riboflavin in hematological and biochemical parameters against arsenic toxicity in Long Evans rat. Sixty male rats were taken to perform the study. Experimental rats were divided into five equal groups. Each group consists of 12 rats. Animals of T0 group were given normal feed and water and kept as control. Rats of T1, were given arsenic trioxide @ 100 mg/L drinking water orally. Rats of group T2 were given arsenic trioxide @ 100 mg/L drinking water and with spirulina @ 1 gm/kg feed. Group T3 were given arsenic trioxide @ 100 mg/L with riboflavin @ 10mg /kg body weight. Group T4 were given arsenic trioxide and spirulina and riboflavin with same dose up to 45 days respectively. Four rats from each group (T0, T1, T2, T3 and T4) were sacrificed at 15 days interval to determine body weight, hematological and biochemical parameters. Result showed that in group T1, body weight gain was minimum, whereas in group T2, T3 and T4 the body weight gain in rats were better. Reduction of TEC, Hb values were significant (P<0.01) in T1 group. Whereas in rest groups reduction of TEC, Hb were less than arsenic treated groups. The values of SGOT and SGPT were significantly (P<0.01) decreased in all group but in it is more effective in combined group. In conclusion, spirulina and riboflavin has significant effect on hematological and biochemical parameters and increase body weight.
Key words: Arsenic, Spirulina, Riboflavin, Hematological and Biochemical parameters.
| Title: | Effect of Spirulina (Spirulina platensis) And Riboflavin Against Arsenic Toxicity In Rat |
|---|---|
| Authors: | Shefaly Akter, Md. Mahmudul Hasan, Rakibul Islam, Fahima Binthe Aziz, Mst. Misrat Masuma Parvez, Sharmin Akter Ripa, Tahmina Akter, & Md. Hannan Ali |
| Journal Name: | International Journal of Science and Business |
| Website: | ijsab.com |
| ISSN: | ISSN 2520-4750 (Online), ISSN 2521-3040 (Print) |
| DOI: | https://doi.org/10.5281/zenodo.1323214 |
| Media: | Online and Print |
| Volume: | 2 |
| Issue: | 3 |
| Acceptance Date: | 28/07/2018 |
| Date of Publication: | 30/07/2018 |
| PDF URL: | https://ijsab.com/wp-content/uploads/263.pdf |
| Free download: | Available |
| Page: | 447-458 |
| First Page: | 447 |
| Last Page: | 458 |
Cite This Article:
Akter, S., Hasan, M. M., Islam, R., Aziz, F. B., Parvez, M. M. M, Ripa, S. A., Akter, T. & Ali, M. H. (2018). Effect of Spirulina (Spirulina platensis) And Riboflavin Against Arsenic Toxicity In Rat. International Journal of Science and Business, 2(3), 447-458.
doi: https://doi.org/10.5281/zenodo.1323214
Retrieved from https://ijsab.com/wp-content/uploads/263.pdf
About Authors
Shefaly Akter (Corresponding Author), Dept. of physiology and pharmacology, Hajee Mohammad Danesh Science and Technology University, Dinajpur-5200, Bangladesh.
Md. Mahmudul Hasan, Dept. of physiology and pharmacology, Hajee Mohammad Danesh Science and Technology University, Dinajpur-5200, Bangladesh.
Rakibul Islam, Dept. of physiology and pharmacology, Hajee Mohammad Danesh Science and Technology University, Dinajpur-5200, Bangladesh.
Fahima Binthe Aziz, Dept. of physiology and pharmacology, Hajee Mohammad Danesh Science and Technology University, Dinajpur-5200, Bangladesh.
Mst. Misrat Masuma Parvez, Dept. of physiology and pharmacology, Hajee Mohammad Danesh Science and Technology University, Dinajpur-5200, Bangladesh.
Sharmin Akter Ripa, Dept. of physiology and pharmacology, Hajee Mohammad Danesh Science and Technology University, Dinajpur-5200, Bangladesh.
Tahmina Akter, Dept. of physiology and pharmacology, Hajee Mohammad Danesh Science and Technology University, Dinajpur-5200, Bangladesh.
Md. Hannan Ali, Dept. of physiology and pharmacology, Hajee Mohammad Danesh Science and Technology University, Dinajpur-5200, Bangladesh.
DOI: https://doi.org/10.5281/zenodo.1323214